Kinetic theory for multicellular systems

On the discrete kinetic theory for active particles. Modelling the immune competition.

This paper deals with the application of the mathematical kinetic theory for active particles, with discrete activity states, to the modelling of the immune competition between immune and cancer cells. The first part of the paper deals with the assessment of the mathematical framework suitable for the derivation of the models. Two specific models are derived in the second part, while some simulations visualize the applicability of the model to the description of biological events characterizing the immune competition. A final critical outlines some research perspectives.

On the discrete kinetic theory for active particles. Mathematical tools.

This paper deals with the development of a mathematical discrete kinetic theory to model the dynamics of large systems of interacting active particles whose microscopic state includes not only geometrical and mechanical variables (typically position and velocity), but also peculiar functions, called activities, which are able to modify laws of classical mechanics. The number of the above particles is sufficiently large to describe the overall state of the system by a suitable probability distribution over the microscopic state, while the microscopic state is discrete. This paper deals with a methodological approach suitable to derive the mathematical tools and structures which can be properly used to model a variety of models in different fields of applied sciences. The last part of the paper outlines some research perspectives towards modelling.